作者单位
Limin Wang,# Wenhui Song,# Stephen Choi, Kai Yu, Feng Zhang, Wei Guo, Yajie Ma,* Kai Wang,*
Fengyu Qu, and Huiming Lin*
Key Laboratory of Photochemical Biomaterials
and Energy Storage Materials, College of Chemistry and
Chemical Engineering, Harbin Normal University, Harbin
150025, China
内容概况
Sonodynamic therapy (SDT) can be described as
ultrasonic (US) catalysis. Adequate charge separation is considered
as effective means to promote reactive oxygen species (ROS).
Here, hollow CoP@N−carbon@PEG (CPCs@PEG) nanospheres
(∼60 nm) are prepared as sonosensitizers, showing greater ROS
generation than pure CoP@PEG under US irradiation. Both 1
O2
and ·O2
− are activation species that are determined by O2 and
electrons. The great SDT performance of CPCs@PEG is ascribed
to the heterostructure which promotes the separation and transfer
for US-generated electrons and holes. In addition, holes can be
further captured by endogenous glucose that is in favor of electron
aggregation and ROS generation. Moreover, the consumption of
glucose would decrease intracellular ATP for starvation therapy.
Given the higher oxidation ability of Co3+, CPCs@PEG nanospheres possess catalase (CAT) activity to convert H2O2 into O2 for
assisting ROS generation. Moreover, they also can oxidize glutathione (GSH) as a mimic GSH oxidase to break intratumor redox
balance, facilitating oxidative stress. More importantly, the nanocomposites reveal good degradation ability dominated by the
oxidation from insoluble phosphide into soluble phosphate, accelerating elimination via urine and feces within 14 days. CPCs@PEG
nanospheres integrate the above effects not only to reveal great tumor inhibition ability but also to excite immune activation for
anticancer.